## Abstract Arabinofuranosylcytosine and its hydrochloride salt (I) are prepared in multiple steps from protected 2‐deoxy‐2‐fluoro‐D‐arabinofuranoside.
Synthesis of new 2′-deoxy-2′-fluoro-4′-azido nucleoside analogues as potent anti-HIV agents
✍ Scribed by Qiang Wang; Weidong Hu; Shuyang Wang; Zhenliang Pan; Le Tao; Xiaohe Guo; Keduo Qian; Chin-Ho Chen; Kuo-Hsiung Lee; Junbiao Chang
- Book ID
- 113583023
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 386 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0223-5234
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Based on the favorable antiviral profiles of 4'-substituted nucleosides, novel 1-(2'-deoxy-2'-fluoro-4'-C-ethynyl-beta-D-arabinofuranosyl)-uracil (1a), -thymine (1b), and -cytosine (2) analogs were synthesized. Compounds 1b and 2 exhibited potent anti-HIV-1 activity with IC(50) values of 86 and 1.34
2 0 -Deoxy-2 0 -fluoro-2 0 -C-methyl nucleoside Anti-HCV activity a b s t r a c t 2 0 -Deoxy-2 0 -fluoro-2 0 -C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication.