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Synthesis of n.c.a. carbon-11 labelled clozapine and its major metabolite clozapine-N-oxide and comparison of their biodistribution in mice

✍ Scribed by Bender, D.; Holschbach, M.; Stöcklin, G.

Book ID: 123464045
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 483 KB
Volume: 21
Category: Article
ISSN: 0969-8051
DOI: 10.1016/0969-8051(94)90080-9

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## Abstract 7‐(CH~3~)~3~N‐4‐{2,4‐(NO~2~)~2~C~6~H~3~S}‐nido‐7‐CB~10~H~11~ has been synthesized through a Friedel‐Crafts substitution reaction on 7‐(CH~3~)3N‐__nido__‐7‐ CB~10~H~12~. A biodistribution study in mice with implanted B16 melanoma indicates that the compound locates in neoplastic tissue a