Asymmetric synthesis of (2S,3S)-3-hydrox
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Jaemoon Lee; Thoa Hoang; Stephanie Lewis; Steven A Weissman; David Askin; R.P Vo
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Article
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2001
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Elsevier Science
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French
β 71 KB
A catalytic highly enantioselective (99% ee) preparation of N-tert-butyloxycarbonyl-(2S,3S)-3-hydroxy-2-phenyl-piperidine and N-tert-butyloxycarbonyl-(2S)-2-phenyl-piperidin-3-one was developed using an intramolecular epoxide opening followed by ring expansion. The cis-epoxide starting material was