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Synthesis of naproxen via regioselective ring opening of (2S,3S)-epoxy-1-butanol

✍ Scribed by Kyo Han Ahn; Chang Soo Jin; Dong Ho Kang; Yong Soon Shin; Jeong Sook Kim; Do Soon Han; Dong H. Kim


Book ID
112130678
Publisher
Journal of Heterocyclic Chemistry
Year
1993
Tongue
English
Weight
182 KB
Volume
30
Category
Article
ISSN
0022-152X

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Asymmetric synthesis of (2S,3S)-3-hydrox
✍ Jaemoon Lee; Thoa Hoang; Stephanie Lewis; Steven A Weissman; David Askin; R.P Vo πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 71 KB

A catalytic highly enantioselective (99% ee) preparation of N-tert-butyloxycarbonyl-(2S,3S)-3-hydroxy-2-phenyl-piperidine and N-tert-butyloxycarbonyl-(2S)-2-phenyl-piperidin-3-one was developed using an intramolecular epoxide opening followed by ring expansion. The cis-epoxide starting material was