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Regioselective Ring Opening of Amino Epoxides with Nitriles: An Easy Synthesis of (2R,3S)- and (2S,3S)-1,3-Diaminoalkan-2-ols with Differently Protected Amine Functions.

✍ Scribed by Jose M. Concellon; Jose Ramon Suarez; Virginia del Solar


Publisher
John Wiley and Sons
Year
2006
Weight
23 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract The two epimers (βˆ’)‐**1a** and (βˆ’)‐**1b** of the macrocyclic lactam alkaloid 3‐hydroxycelacinnine with the (2__R__,3__R__) and (2__R__,3__S__) absolute configurations, respectively, were synthesized by an alternative route involving macrocyclization with the regio‐ and stereoselective o