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Synthesis of N6,N6-Dialkyladenine Nucleosides Using Hexaalkylphosphorus Triamides Produced in Situ

✍ Scribed by Mahesh K. Lakshman; Asad Choudhury; Suyeal Bae; Eliezer Rochttis; Padmanava Pradhan; Amit Kumar


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
342 KB
Volume
2009
Category
Article
ISSN
1434-193X

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Herein we report the facile conversion of 2 ,3 ,5 -tri-O-acetylinosine to three different nucleoside analogs via reaction of hexamethylphosphorous triamide and an organic halide. Acetyl-protected 6-bromopurine riboside, 6-chloropurine riboside and N 6 ,N 6 -dimethyladenosine can each be prepared in