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ChemInform Abstract: C6 Substitution of Inosine Using Hexamethylphosphorous Triamide in Conjunction with Carbon Tetrahalide or N-Halosuccinimide.

✍ Scribed by Eduardo A. Veliz; Peter A. Beal

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
31
Category
Article
ISSN
0931-7597

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C6 substitution of inosine using hexamet
C6 substitution of inosine using hexamethylphosphorous triamide in conjunction with carbon tetrahalide or N-halosuccinimide
✍ Eduardo A VΓ©liz; Peter A Beal πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 83 KB

Herein we report the facile conversion of 2 ,3 ,5 -tri-O-acetylinosine to three different nucleoside analogs via reaction of hexamethylphosphorous triamide and an organic halide. Acetyl-protected 6-bromopurine riboside, 6-chloropurine riboside and N 6 ,N 6 -dimethyladenosine can each be prepared in