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Synthesis of N -substituted isoindolinones via a palladium catalysed three-component carbonylation – amination – Michael addition cascade

✍ Scribed by Grigg, Ronald; Gai, Xinjie; Khamnaen, Tossapol; Rajviroongit, Shuleewan; Sridharan, Visuvanathar; Zhang, Lixin; Collard, Simon; Keep, Ann


Book ID
125537610
Publisher
NRC Research Press
Year
2005
Tongue
French
Weight
164 KB
Volume
83
Category
Article
ISSN
0008-4042

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Isoindolinones via a room temperature pa
✍ Ronald Grigg; Lixin Zhang; Simon Collard; Ann Keep 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 142 KB

A room temperature 3-component cascade process involving nucleophilic substitution/carbonylation/amination, catalysed by palladium nanoparticles generated in situ from palladacycle 5, affords isoindolinones in good yields. The conversions correlate with the pK a values of the amines.