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Synthesis of N-substituted indoles by extractive alkylation

✍ Scribed by N. N. Suvorov; Yu. I. Smushkevich; V. S. Velezheva; V. S. Rozhkov; S. V. Simakov

Book ID
112362065
Publisher
Springer US
Year
1976
Tongue
English
Weight
220 KB
Volume
12
Category
Article
ISSN
0009-3122

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An expedient synthesis of 3-substituted
An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones
✍ John R. Rizzo; Charles A. Alt; Tony Y. Zhang πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 French βš– 146 KB

3-Alkylindoles were prepared in one step from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid. Under this particular condition, unsubstituted indoles could be tolerated to afford good yields of 3-sec-alkylation products.