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Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

โœ Scribed by David J Madar; Hana Kopecka; Daisy Pireh; Jonathan Pease; Marina Pliushchev; Richard J Sciotti; Paul E Wiedeman; Stevan W Djuric

Book ID
104230625
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
66 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A method for the intermolecular coupling of aryl bromides and oxazolidinones is described. Application to intermediates useful for the preparation of a known class of antibacterial agent and the synthesis of the known antibacterial oxazolidinone Dup-721 are described.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of chiral N-aryl pyrrolidinone
Synthesis of chiral N-aryl pyrrolidinones via a palladium-catalyzed cross-coupling reaction
โœ R.Greg Browning; Hossen Mahmud; Vivek Badarinarayana; Carl J Lovely ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 62 KB

The direct synthesis of non-racemic N-aryl pyrrolidinones through the application of the Buchwald/Hartwig aryl amination reaction is reported. These reactions proceed in generally good yield, with a variety of electron deficient aryl bromides and with retention of stereochemical purity.