Synthesis of chiral N-aryl pyrrolidinones via a palladium-catalyzed cross-coupling reaction
β Scribed by R.Greg Browning; Hossen Mahmud; Vivek Badarinarayana; Carl J Lovely
- Book ID
- 104231551
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 62 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The direct synthesis of non-racemic N-aryl pyrrolidinones through the application of the Buchwald/Hartwig aryl amination reaction is reported. These reactions proceed in generally good yield, with a variety of electron deficient aryl bromides and with retention of stereochemical purity.
π SIMILAR VOLUMES
Unsymmetrical biaryls bearing electron-donating and electron-withdrawing functional groups have been obtained in an efficient manner by Pd-catalyzed coupling of aryl halides. Aryl bromides react with aryl iodides to yield unsymmetrical biaryls with marked selectivity.
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