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Synthesis of chiral N-aryl pyrrolidinones via a palladium-catalyzed cross-coupling reaction

✍ Scribed by R.Greg Browning; Hossen Mahmud; Vivek Badarinarayana; Carl J Lovely


Book ID
104231551
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
62 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


The direct synthesis of non-racemic N-aryl pyrrolidinones through the application of the Buchwald/Hartwig aryl amination reaction is reported. These reactions proceed in generally good yield, with a variety of electron deficient aryl bromides and with retention of stereochemical purity.


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Synthesis of unsymmetrical biaryls via p
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Unsymmetrical biaryls bearing electron-donating and electron-withdrawing functional groups have been obtained in an efficient manner by Pd-catalyzed coupling of aryl halides. Aryl bromides react with aryl iodides to yield unsymmetrical biaryls with marked selectivity.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v