Synthesis of N-Aryl Hydrazides by Copper-Catalyzed Coupling of Hydrazides with Aryl Iodides
β Scribed by Wolter, Martina; Klapars, Artis; Buchwald, Stephen L.
- Book ID
- 111691019
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 54 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
An efficient copper-catalyzed carbon-nitrogen bond formation is described. The copper(I) complex with commercially available 2-picolinic acid ligand was found to be effective in N-arylation of N-Boc-hydrazine. This methodology offers a regioselective N-arylation of hydrazides using a variety of subs
Substituted aryl bromides are coupled with t-butylcarbazate in the presence of a palladium catalyst and base to afford regioselectively, the corresponding amidation product or amination product depending upon the position of the substituents on the aryl bromide.
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