Synthesis of N-acridinyl and N-quinolinyl derivatives of radioprotective amino-thiols

✍ Scribed by Patrice Demonchaux; Ali Laayoun; Martine Demeunynck; Jean Lhomme

• Book ID: 104204816
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 763 KB
• Volume: 45
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)89522-3

✦ Synopsis

A series of bifunctional molecules in which a heterocycle is linked to an aminothiol chain were synthesized. A new synthesis of N,N'-bis-(3-aminopropyl) cystamine (WR 33278) is described. Reaction of WR 33278 or analogues with the phenoxy derivatives of quinoline or acridine yielded the desired bifunctional molecules. Aminothiols, the structures of which are derived from cysteamine 1, constitute class of radioprotective agents. Among them, (aminopropyl) aminoethyl phosphorothioTc acid 2 (WR-2721) is described as the most effective compound in the series * 7-chloro-2-methoxy-9-phenoxyacridine 9 was prepared as described in the literature (13).