Starting fro enolizing 1.2~diketones 1 and (2,2dlathoxyvinylidene)triphenylphosphorane (1) or from 2 and (2.2-dlethoxyvlnyl)triphewlphosphonlu tetrafluorohorate (a) the orthoesters 2 are prepared. 9 can be hydrolyzed under acldlc conditions to glve 5-alkylldene-2(SH)-furan%es lo. Reaction of 1,2-hyd
✦ LIBER ✦
Synthesis of (+)-muscarine from (S)-(−)-5-hydroxymethyl-2(5H)-furanone
✍ Scribed by Kyung Ho Kang; Mi Young Cha; Ae Nim Pae; Kyung Il Choi; Yong Seo Cho; Hun Yeong Koh; Bong Young Chung
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 74 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
+)-Muscarine has been synthesized from (S)-(-)-5-hydroxy-2(5H)-furanone via rather a long pathway to provide easy access to a wide variety of its analogues.
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