A concise synthesis of anti-viral agent
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Anusuya Choudhury; Fuqiang Jin; Dengjin Wang; Zhe Wang; Guoyou Xu; Dieu Nguyen;
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Article
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2003
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Elsevier Science
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French
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Anti-HIV agent b-F-ddA (1) has been synthesized starting from readily available non-sugar, (S)-(+)-Dihydro-5-(hydroxymethyl)-2-(3H)-furanone (4). A highly syn-stereoselective fluorination of the hydroxy lactone 2 generates the key intermediate fluorolactone 5 in a short and concise synthetic sequenc