𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of multilabeled histidine

✍ Scribed by Caroline Soohoo; John A. Lawson; Joseph I. Degraw

Book ID
102369946
Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
244 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of tetralabeled histidine 15 described. Glycine‐^15^N was converted essentially by literature procedures to 4‐chloromethylimidazole‐3‐^15^N‐2,5‐^2^H~2~. Alkylation of ethyl acetamidocyanoacetate‐2‐^13^C, followed by acid hydrolysis and decarboxylation yielded DL‐histidine‐α‐ ^13^C‐3‐^15^N‐2,5‐^2^H~2~. The compound is useful as a mass spectrometric standard for the measurement of histidine and metabolites in biological media.

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