Synthesis of montiporynes A and B
โ Scribed by Traci J Speed; Dasan M Thamattoor
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 59 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Montiporynes A and B, that were among the recently isolated diacetylenic ketones from the stony coral Montipora sp., and reported to possess in vitro cytotoxic activity against several human solid tumor cells, have been synthesized in three simple steps from readily available materials.
๐ SIMILAR VOLUMES
In this paper we report the development of a stereoselective IMDA approach to the phytotoxic polyketides (ยฑ)-solanapyrones A and B. The stereoselectivity of the key IMDA cycloaddition was optimized by investigating a range of 2,8,10-dodecatrienoic acid derivatives. This established that use of the W