## Abstract The enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6‐chloropurine riboside and the corresponding 2′,3′‐__O__‐isopropylidene derivative, but show no activity towards the 3,4‐__O__‐isopropylidene‐1‐methylriboside of
Synthesis of Modified Purine Nucleosides and Related Compounds Mediated by Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA)
✍ Scribed by Enzo Santaniello; Pierangela Ciuffreda; Laura Alessandrini
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Abstract Selected 2,6‐(disubstituted)purine 2′,3′‐didehydro‐2′,3′‐dideoxynucleosides and 2′,3′‐dideoxynucleosides were prepared and evaluated. Treatment of 5′‐protected ribonucleosides with phenoxythiocarbonyl chloride and 4‐(dimethylamino)pyridine, or under Schotten‐Baumann conditions, gave hig