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Activity of Adenosine Deaminase (ADA) and Adenylate Deaminase (AMPDA) Towards 6-Chloropurine Nucleosides Modified in the Ribose Moiety

✍ Scribed by Pierangela Ciuffreda; Benedetta Buzzi; Laura Alessandrini; Enzo Santaniello

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 115 KB
Volume: 2004
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200400380

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✦ Synopsis

Abstract

The enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6‐chloropurine riboside and the corresponding 2′,3′‐O‐isopropylidene derivative, but show no activity towards the 3,4‐O‐isopropylidene‐1‐methylriboside of 6‐chloropurine and adenine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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