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Synthesis of miltirone by an ultrasound-promoted cycloaddition

✍ Scribed by Lee, Junning; Mei, Hsiao Shan; Snyder, John K.


Book ID
124068369
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
537 KB
Volume
55
Category
Article
ISSN
0022-3263

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The 2-iodomethyl-O-isopropylidine acetals undergo smoothly b-elimination by indium metal in methanol under sonication to afford the corresponding allylic alcohols in excellent yields with high selectivity. This method tolerates both acid and base labile functional and protecting groups and also free