The 2-iodomethyl-O-isopropylidine acetals undergo smoothly b-elimination by indium metal in methanol under sonication to afford the corresponding allylic alcohols in excellent yields with high selectivity. This method tolerates both acid and base labile functional and protecting groups and also free
Ultrasound-Accelerated Synthesis of Chiral Allylic Alcohols Promoted by Indium Metal.
โ Scribed by J. S. Yadav; B. V. S. Reddy; K. Srinivasa Reddy
- Book ID
- 101950843
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 91 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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1997 organo-selenium compounds, acyclic C derivatives organo-selenium compounds, acyclic C derivatives S 0132 ## 22 -189 Novel Synthesis of Allyl and Propargyl Selenides Promoted by Indium. -Indium-promoted reaction of allylic and propargylic bromides with diorganyl diselenides provides the corre
Allylic and propargyl bromides react smoothly with diorganyl diselenides in aqueous media to give allylic and propargyl selenides in moderate to good yields. The reaction need not be carried out in inert atmosphere. The speed is quicker than the same reactions in organic media.