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Synthesis of milbemycins from avermectins

โœ Scribed by H. Mrozik; J.C. Chabala; P. Eskola; A. Matzuk; F. Waksmunski; M. Woods; M.H. Fisher


Book ID
104221271
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
295 KB
Volume
24
Category
Article
ISSN
0040-4039

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Synthesis of the monocyclic nonaromatic
โœ Neville J. Anthony; Trafford Clarke; A. Brian Jones; Steven V. Ley ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 241 KB

The efficient synthesis of C-l to C-10 monocyclic nonaromatic fragments of the milbemycins and avermectins has been achieved, in which the key step involved the stereoselective addition of 2-lithio-4-phenylthiobut-1-ene to a 3-hydroxycyclohexanone derivative.