Recent years have seen a remarkable surge of interest in the study of U-Lfucosyltransferases. Of these L-fucosyltransferases, the enzyme (143)~a+fucosyltransferase has attracted a great deal of clinical interest as a potential tumor marker. This enzyme catalyzes the transfer of an L-fucosyl group f
Synthesis of methyl O-(β-d-galactopyranosyl)-(1→3)-O-[α-l-fucopyranosyl-(1→4)]-2-acetamido-2-deoxy-6-O-sulfoβ -d-glucopyranoside sodium salt as a potential ligand for selectin molecules
✍ Scribed by Rakesh Vig; Rakesh K. Jain; Khushi L. Matta
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 511 KB
- Volume
- 266
- Category
- Article
- ISSN
- 0008-6215
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Halide-assisted glycosyIation, using a non-p~icipating Z-substituent (benzyl) in the glycosyl halide, was used to obtain the ~-D-gaiactosyl linkage and silver triflate promotion with a participating 2-substituent (benzoyl) was used to obtain the /3-D-galactosyl linkage in a facile synthesis of the t
Treatment of benzyl O-/?-n-galactopyranosyl-( 1+3)-2-acetamido-2-deoxy-4,6-O-isopropylidene-j3-D-glucopyranoside with tert-butylchlorodiphenylsiiane afforded the 6'-0-tert-butyldiphenylsilyl ether, which was converted into the 3',4'-0-isopropylidene derivative. Methylation and subsequent removal of