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Synthesis of medium-sized carbocyclic ketones via the intramolecular B-alkyl Liebeskind–Srogl coupling reaction

✍ Scribed by Kazuhiro Tsuna; Naoyoshi Noguchi; Masahisa Nakada

Book ID
113930231
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
227 KB
Volume
52
Category
Article
ISSN
0040-4039

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Synthesis of Small and Medium Sized 2,2-Disubstituted Lactams via the " Intramolecular" Three Component Ugi Reaction. -Tethered keto-acids undergo an intramolecular three-component Ugi reaction with a variety of primary amines and isocyanates to form five-to eight-membered lactams in good yields. -(