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Synthesis of Macrocyclic Dilactones Through Lipases.

✍ Scribed by M. Pilar Bosch; Angel Guerrero


Book ID
101986548
Publisher
John Wiley and Sons
Year
2006
Weight
15 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract A small number of macrocyclic dilactones of type **3**, __i.e.__, **9, 10, 11**, and epi‐**11**, comprising a 3,4‐dihydroxypentanoic acid unit, the pharmacophore of aplysiatoxin, and a conformationally preorganized __Ο‰__‐hydroxynonanoic acid unit were synthesized. Conformational analysi