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Synthesis of macrocyclic dilactones by cyclization of sulfonium salts

✍ Scribed by Nakamura, Takako; Matsuyama, Haruo; Kamigata, Nobumasa; Iyoda, Masahiko


Book ID
118152000
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
973 KB
Volume
57
Category
Article
ISSN
0022-3263

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## Abstract A small number of macrocyclic dilactones of type **3**, __i.e.__, **9, 10, 11**, and epi‐**11**, comprising a 3,4‐dihydroxypentanoic acid unit, the pharmacophore of aplysiatoxin, and a conformationally preorganized __Ο‰__‐hydroxynonanoic acid unit were synthesized. Conformational analysi