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Synthesis of Lipid A Derivatives and Their Interactions with Polymyxin B and Polymyxin B Nonapeptide

✍ Scribed by Yin, Ning; Marshall, Ryan L.; Matheson, Sannali; Savage, Paul B.


Book ID
126826450
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
167 KB
Volume
125
Category
Article
ISSN
0002-7863

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The interactions of the antibiotic polymyxin BI and its enzymatic cleavage product polymyxin B~ nonapeptide with phosphatidic acid monolayers and with bilayer membranes were investigated. Temperature-dependent pressure-arca analysis of the monolayer reveals a linear increase of the lipid mean molecu