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N-terminal modifications of Polymyxin B nonapeptide and their effect on antibacterial activity

✍ Scribed by Haim Tsubery; Itzhak Ofek; Sofia Cohen; Mati Fridkin


Book ID
117408109
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
194 KB
Volume
22
Category
Article
ISSN
0196-9781

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Lipases A and B from CJugosa have been chemically modified with octanoyl chloride or polyethylene glycol (molecular weight: 750 or 5000). Although the hydrolytic activity was diminished, modification gave rise in some cases to preparations with increased synthetic activity in hexane. Furthermore, PE