Synthesis of linear unidecapeptide precursors of cyclosporin analogues
✍ Scribed by I.J. Galpin; A.K.A. Mohammed; A. Patel
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 982 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
Syntheses of cyclosporine analogues are reported wherein the peptide couplings were achieved in solid phase. The Wang resin was used as the solid support, and the peptide couplings commenced with the residue 11 of the cyclosporine skeleton. The couplings proceeded in a stepwide manner up to the res
## Abstract The relative configuration and conformation of the 8‐methyl‐5‐nitro‐1‐oxo‐Δ^8(8a)^‐octahydronaphthalene isomers were elucidated by various ^1^H and ^13^C NMR methods. The structure of the tricyclic by‐products was also determined.