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Synthesis of (−)-Lasubine(I) via a Planar Chiral [(η 6 -arene)Cr(CO) 3 ] Complex

✍ Scribed by Ratni, Hassen; Kündig, E. Peter


Book ID
127105191
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
126 KB
Volume
1
Category
Article
ISSN
1523-7060

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Reaction of lithium hexamethyldisilazide (LHMDS) with Cq6-arene)Cr(CO)3 complexes bearing a ~-alaninenitrile moiety gives tetrahydroisoquinoline derivatives as the major products after oxidation of the reaction intermediate, whereas protonation of the reaction intermediates produces hexahydroisoquin