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Synthesis of labelled nordihydroguaiaretic acid

✍ Scribed by Carrie Y.-C. Chan; M. A. Leaffer; R. M. Parkhurst; D. W. Thomas; L. M. Allen; R. T. Jordan; R. S. Pardini


Book ID
102371637
Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
321 KB
Volume
22
Category
Article
ISSN
0022-2135

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## Abstract A convenient synthesis is reported of lithocholic acid labelled in high isotopic purity with two atoms of deuterium at C‐11. Incorporation of deuterium is achieved by base‐catalyzed equilibration of a 12‐oxo bile acid in heavy water. The product is converted __in situ__ into its tosylhy