Using 1 -chloro-l-[~~N]nitrosocyclohexane, we have prepared five L-[a-'SN]arnino acids. The stereoselective electophillic hydroxyamination of (S)-acylbornane-l0,2-suftams, followed by ZnO/H+ reduction, and alkaline cleavage of the chiral auxiliary, gave the amino acids in 97.2-99.5 % e.e. By starti
Synthesis of labeled L-cystinyl-bis-L-valine and bis-6-(L-2-aminoadipyl)-L-cystinyl-bis-L-valine
✍ Scribed by H. Vanderhaeghe; P. Adriaens
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- French
- Weight
- 349 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The synthesis of two peptides, L‐cystinyl‐bis‐L‐valine and bis‐6‐(L‐2‐aminoadipyl)‐L‐cystinyl‐bis‐L‐valine, labeled with L‐valine‐^14^C(U) or L‐cystine‐3,3′‐T, is described.
📜 SIMILAR VOLUMES
## Abstract A new tripeptide, L‐α‐aminoadipyl‐L‐seryl‐D‐valine has been synthesized by coupling the protected L‐seryl‐D‐valine dipeptide with an appropriately protected L‐α‐aminoadipic acid ester. The free tripeptide was obtained after treatment with liquid HF and purification by HPLC.
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