Synthesis of L-tryptophan labeled with hydrogen isotopes in the indole ring
✍ Scribed by E. Winnicka; M. Kańska
- Book ID
- 106440604
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 186 KB
- Volume
- 279
- Category
- Article
- ISSN
- 1588-2780
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## Abstract The synthesis of selectively ^14^C‐labeled l‐tryptophan and its derivative 5‐hydroxy‐l‐tryptophan using chemical and multienzymatic methods is reported. The mixture containing [1‐^14^C[‐dl‐alanine, indole or 5‐hydroxyindole has been converted to [1‐^14^C]‐l‐tryptophan or 5′‐hydroxy‐[1‐^
## Abstract The enzymatic synthesis of l‐tryptophan and its derivative 5′‐hydroxy‐l‐tryptophan labeled with deuterium and tritium at the α‐carbon position is reported. The mixture containing __S__‐methyl‐l‐cysteine, indole or 5‐hydroxyindole dissolved in deuteriated or tritiated water has been conv
## Abstract Phenylalanines regiospecifically labelled with deuterium in the aromatic ring can be prepared through the hydrogenolysis of tyrosine tetrazolyl ethers using D~2~ gas and a medium pressure catalytic hydrogenator.