Synthesis of L-Sugars from 4-Deoxypentenosides.
β Scribed by Fabien P. Boulineau; Alexander Wei
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
For Abstract see ChemInform Abstract in Full Text.
π SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
Cyclophosphamide la is a highly effective and extensively used agent for the treatment of human cancers'. The metabolism, pharmacokinetics, and mechanism of action of la have been the subject of several recent reviews2-5. The activation process of la involves initial hydroxylation by the hepatic cyt
acid (4b) are reported. The syntheses exploit the diastereoselective oxidation of the 5,6-double bond of the quinic acid-derived lactone 2 with osmium tetroxide.