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Synthesis of l -Carbafuranomycin, an Unnatural Analogue of the Antibiotic Amino Acid Furanomycin †,‡

✍ Scribed by Lee, Ja Young; Schiffer, Guido; Jäger, Volker


Book ID
126224116
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
69 KB
Volume
7
Category
Article
ISSN
1523-7060

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The nucleus of the carbacephem antibiotic loracarbef was synthesized in a highly efficient and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which was derived from enzyme-catalyzed condensation of glycine and 4-pentenaldehyde. The bicyclic framework of this compound