Synthesis of L-4-amino-3-isoxazolidinone, the unnatural stereoisomer of cycloserine and its antibiotic activity
✍ Scribed by J. Smrt; J. Beránek; J. Sicher; J. Škoda; V. F. Hess; F. Šorm
- Book ID
- 112704549
- Publisher
- Springer
- Year
- 1957
- Tongue
- English
- Weight
- 135 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1420-682X
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In order to elucidate the essential core structure of potent the five stereoisomers thus obtained for the six glycosidases has demonstrated the 2/3,4,5) and (1,2,3,4,5/0) isomers α-mannosidase inhibitors, e.g. mannostatin A, 5-amino-5-Cmethyl-1,2,3,4-cyclopentanetetrols 4-8 were designed and to be m
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract (3__R__,4__R__)‐3‐Amino‐4‐hydroxyhexahydroazepine (2), the optically active constituent of the antifungal antibiotic ophiocordin (1), was prepared in a multistep synthesis starting from D‐serine. The absolute configuration was unambigously assigned by a comparison of the synthesized ste