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Synthesis of isomeric 2,3,5-trisubstituted perhydropyrrolo[3,4-d]-isoxazole-4,6-diones via 1,3-dipolar cycloaddition reactions

✍ Scribed by Hamdi Özkan; Yilmaz Yildirir

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 105 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.395

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✦ Synopsis

Abstract

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A series of isoxazolidine derivates (isomeric 2,3,5‐trisubstitutedperhydropyrrolo[3,4‐d]isoxazole‐4,6‐diones) used as anti‐inflammatory, immunosuppressive, antibacterial agent, and inhibitor for some enzymes were synthesized. These compounds were prepared by 1,3‐dipolar cycloaddition of N‐methyl maleimide and N‐phenyl maleimide with nitrones. Diastereomeric products obtained in this reaction were separated by column chromatography and recrystallized. All compounds synthesized were characterized by elemental analysis and spectroscopic methods (^1^H NMR, ^13^C NMR, and FTIR). J. Heterocyclic Chem., (2010).

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