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Synthesis of Isocoumarins through Three-Component Couplings of Arynes, Terminal Alkynes, and Carbon Dioxide Catalyzed by an NHC-Copper Complex

✍ Scribed by Yoo, Woo-Jin; Nguyen, Thanh V. Q.; Kobayashi, Shū


Book ID
126947431
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
491 KB
Volume
53
Category
Article
ISSN
0044-8249

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An efficient three-component coupling of aldehydes, amines and alkynes to prepare propargylamines, in nearly quantitative yields using nanocrystalline CuO as a catalyst is described. Structurally divergent aldehydes and amines were converted to the corresponding propargylamines. The reaction does no