An efficient synthesis of propargylamines via three-component coupling of aldehydes, amines and alkynes catalyzed by nanocrystalline copper(II) oxide

✍ Scribed by M. Lakshmi Kantam; Soumi Laha; Jagjit Yadav; Suresh Bhargava

• Book ID: 104095215
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 112 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.03.053

✦ Synopsis

An efficient three-component coupling of aldehydes, amines and alkynes to prepare propargylamines, in nearly quantitative yields using nanocrystalline CuO as a catalyst is described. Structurally divergent aldehydes and amines were converted to the corresponding propargylamines. The reaction does not require any co-catalyst. After completion of the reaction, the catalyst was recovered by centrifugation and reused several times with only a slight decrease of activity observed under the same reaction conditions.