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Synthesis of indolizidine, pyrrolizidine and quinolizidine ring systems by proline-catalyzed sequential α-amination and HWE olefination of an aldehyde

✍ Scribed by Kauloorkar, Shruti Vandana; Jha, Vishwajeet; Kumar, Pradeep


Book ID
126053302
Publisher
The Royal Society of Chemistry
Year
2013
Tongue
English
Weight
437 KB
Volume
3
Category
Article
ISSN
2046-2069

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✍ Sharad P. Panchgalle; Ganesh F. Jogdand; Subhash P. Chavan; Uttam R. Kalkote 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 291 KB

An efficient enantioselective synthesis of (R)-(+)-a-lipoic acid is described, in high optical purity (>97% ee), using L-proline-catalyzed sequential a-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde as the key step.