Enantioselective synthesis of (R)-(+)-α-
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Sharad P. Panchgalle; Ganesh F. Jogdand; Subhash P. Chavan; Uttam R. Kalkote
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Article
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2010
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Elsevier Science
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French
⚖ 291 KB
An efficient enantioselective synthesis of (R)-(+)-a-lipoic acid is described, in high optical purity (>97% ee), using L-proline-catalyzed sequential a-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde as the key step.