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Synthesis of indole, benzofuran and benzothiophene by reaction of 2-anilinoethanol, 2-phenoxyethanol and 2-(phenylthio)ethanol on AlPO4 and Pd/AlPO4 catalysts

✍ Scribed by Jean Afxantidis; Naima Bouchry; Jean-Pierre Aune

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
799 KB
Volume
102
Category
Article
ISSN
1381-1169

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✦ Synopsis

The synthesis of indole, benzofuran and benzotbiophene is possible from compounds of the general formula: @X-CH,-CH,_OH (X = NH, 0, S). The reaction of 2-anilinoethanol, 2-phenoxyethanol and 2-(phenylthio) ethanol on aluminium orthophosphate and palladium supported by aluminium ortbophosphate catalysts was studied. The synthesis of benzotbiophene over AWO, was optimized by the response surface methodology. A possible mechanistic pathway involving an acid media cyclization is discussed.

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