Synthesis of Imidazopyridines and Purines as Potent Inhibitors of Leukotriene A4 Hydrolase
✍ Scribed by Thomas D Penning; Nizal S Chandrakumar; Bipin N Desai; Stevan W Djuric; Alan F Gasiecki; James W Malecha; Julie M Miyashiro; Mark A Russell; Leslie J Askonas; James K Gierse; Elizabeth I Harding; Maureen K Highkin; James F Kachur; Suzanne H Kim; Doreen Villani-Price; E.Yvonne Pyla; Nayereh S Ghoreishi-Haack; Walter G Smith
- Book ID
- 108477420
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 124 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0960-894X
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## Abstract BCX‐1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme‐catalyzed CN bond cleavage of nucleosides. BCX‐1777 is a slow‐onset, tight‐binding inhibitor with a __K__~__i__~^\*^ o
AbstractÐSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxy¯uoro-and 2-deoxy-analogues and others having modi®ed bases.