Synthesis of hydroxamic acids using SynPhase™ crowns: Development of the hydroxylamine trityl linker
✍ Scribed by Nicholas J. Ede; Ian W. James; Beata M. Krywult; Rachael M. Griffiths; Susan N. Eagle; Ben Gubbins; Jeffrey A. Leitch; Wayne R. Sampson; Andrew M. Bray
- Book ID
- 110269071
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 72 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1573-3149
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The development of novel linkers and linkage strategies has become essential in solid-phase synthesis for the discovery of new drugs and materials. In recent years, many efficient linkers were developed. [1] Traceless linkers are advantageous in that the original functional group of the linker does
1999 carboxylic acid derivatives carboxylic acid derivatives (acyclic compounds) P 0340 ## 01 -080 New Hydroxylamines for the Synthesis of Hydroxamic Acids. -As part of a program concerning design and synthesis of inhibitors of TNFα convertase, hydroxylamines are prepared and coupled with carboxy