ChemInform Abstract: New Hydroxylamines for the Synthesis of Hydroxamic Acids.

✍ Scribed by B. BARLAAM; A. HAMON; M. MAUDET

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199901080

✦ Synopsis

1999 carboxylic acid derivatives carboxylic acid derivatives (acyclic compounds) P 0340

01 -080

New Hydroxylamines for the Synthesis of Hydroxamic Acids.

-As part of a program concerning design and synthesis of inhibitors of TNFα convertase, hydroxylamines are prepared and coupled with carboxylic acids under standard conditions. The protected hydroxamates can be easily deprotected with TFA. Compound (IV) is of biological interest. -(BARLAAM,