Phosphopeptides are a useful tool for the investigation of phosphorylation as a reversible posttranslational modification. There is a growing interest in using mimics of phosphoamino acids involved in phosphorylation in order to study the enzymes concerned in these processes. These mimics should con
Synthesis of homoserine phospho-, H-phosphono- and methylphosphonopeptides
✍ Scribed by Andreas Tholey; Rüdiger Pipkorn; Michael Zeppezauer; Jennifer Reed
- Publisher
- Springer Netherlands
- Year
- 1998
- Tongue
- English
- Weight
- 396 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1573-3149
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📜 SIMILAR VOLUMES
Two new syntheses OP L-homoserine and its derivatives are described and a rearrangement which aonverta an L-homoserlne derivative into a protected &-azetidine carboxylic acid is discussed. -
Two phosphono desmuramyldipeptide analogs, 6 and 11, were synthesized and evaluated for immunomodulatory activity. Phthalimido-and adamantyl-substituted side chains as a replacement for the N-acetylmuraminic acid were coupled with appropriate dipeptides using DPPA as the coupling reagent. Introducti
The synthesis of six regiospecific deuterated D,L-homoserine lactone hydrochlorides from the appropriately deuterated 2-bromo-1 -(tetrahydropyranyloxy) ethanes which were obtained by reduction of the corresponding ethyl bromoacetates are described. The proton nmr of each lactone is recorded and the
Abstractz Aminophosphine-ylides 4a and 4b were prepared in high yields by treating 3-acetyl coumarins la and lb with trisdimethylaminophosphine 2. Chemical degradation reactions for the ylides 4a,b (e.g., formation of the phosphonium salt, Wittig reaction, hydrolysis) were suggested and illustrated.