Synthesis of highly enantioenriched hydroxy- and dihydroxy-fatty esters: substrate precursors for cytochrome P450BioI

Chiral α-hydroxy- and α,β-dihydroxy- ald

Chiral α-hydroxy- and α,β-dihydroxy- aldehydes from D-isoascorbic and L-ascorbic acids. Useful precursors for the synthesis of fatty acid metabolites.

✍ Y Le Merrer; C Gravier-Pelletier; J Dumas; J.C Depezay 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 273 KB

&mm6fy : The four possible stereoisomers of a$dihydroxyaldehydes, useful building blocks for the synthesis of fatty acids metabolites, are synthesized via epoxy-tetrols derived from D-isoascorbic and L-ascorbic acids. The general method we develop allows the synthesis of chiral a-hydroxyaldehydes as