Synthesis of acyclic nucleoside phosphon
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Frank WormstΓ€dt; Michael GΓΌtschow; Kurt Eger; Ute Brinckmann
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Article
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2000
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Journal of Heterocyclic Chemistry
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English
β 426 KB
## Abstract Reaction of 6βchloropyrimidines with diethyl [(2βaminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5βsubstituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (