✦ LIBER ✦

Synthesis of high specific activity carbon-14 labeled PD-113,926 and CI-930, potential new cardiotonic agents

✍ Scribed by Sheryl J. Hays; James L. Hicks; C. C. Huang

Book ID: 102375708
Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 402 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580241006

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✦ Synopsis

Double-lapgled PD-113,926 and CI-930 were synthesized from [ C]MeI and [ C]BaCO respectively in high specific activity (290 mCi/mmol). The &thesis of CI-930 employed the intermediate 2-b~tenenitrile-3,4-~'C which was synthesized by a phase transfer Wittig procedure. to good yields of olefin and accommodates the use of aqueous solutions of aldehydes. This%ittig procedure is fast, produces moderate

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