Synthesis of helminthogermacrene and β-elemene
✍ Scribed by John E. McMurry; Pavel Kočovský
- Book ID
- 104229105
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 107 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Helminthogermacrene (1) and $-elemene (3) have been synthesized by a short route starting from geranylacetone. Titanium-induced cyclization of 3-isopropenyl-6-methyl-lo-oxo-6&undecenal
(7) was used as the key step.
📜 SIMILAR VOLUMES
In previous papers we described the isolation of a new germacrane derivative, ageratriol I('), and of a new sesquiterpenic alcohol, p-elemen-qp-ol II (2) ,from Achilles ageratum L. (Compositae).
## Abstract __β__‐Elemene, (1__S__, 2__S__, 4__R__)‐(−)‐(1‐methy‐1‐vinyl‐2,4‐diisopropenyl cyclohexane) is an anticancer agent from the __Traditional Chinese Herb Medicinal__. Three novel Re(CO)~3~‐__β__‐elemene derivatives including their radioactive conjugates containing __N__,__N__,__N__ trident