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Synthesis of hapten–phosphoramidites from 2′-deoxyuridine

✍ Scribed by Maciej Adamczyk; Srinivasa Rao Akireddy; Phillip G Mattingly; Rajarathnam E Reddy


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
622 KB
Volume
59
Category
Article
ISSN
0040-4020

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a b s t r a c t 5-Hydroxymethylcytosine has recently been characterized as the 'sixth base' in human DNA. To enable research on this DNA modification, we report an improved method for the synthesis of 5-hydroxymethyl-2 0 -deoxycytidine ( 5-HOMe dC) phosphoramidite for site-specific incorporation int