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Synthesis of (±)-Hamigeran B, (−)-Hamigeran B, and (±)-1 -epi -Hamigeran B: Use of Bulky Silyl Groups to Protect a Benzylic Carbon−Oxygen Bond from Hydrogenolysis

✍ Scribed by Clive, Derrick L. J.; Wang, Jian


Book ID
121262379
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
302 KB
Volume
69
Category
Article
ISSN
0022-3263

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Stereospecific Total Synthesis of the An
✍ Derrick L. J. Clive; Jian Wang 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

We report the stereospecific synthesis of hamigeran B (1, Scheme 1), which is an important member of a group of related compounds isolated [1] from a marine sponge. Hamigeran B has been found to have strong in vitro activity against polio and herpes viruses but little cytotoxicity. [1] The compound